Humans exist, though in myriad forms.

Non-human sapient life-forms exist, but none of them are at all “humanoid” in any way. If it looks at all human, it came from human stock at one point.

With so many kinds of humans and other intelligent life forms, technology varies considerably. We will enumerate what definitely does exist somewhere, or does not exist anywhere.

Interstellar travel is possible in time-frames that allow it to be part of plots.

Travel is limited, such that there are frontiers and backwaters, and such that are more difficult to get to.